CAD and creativity: does the computer really help?

We are frequently told by its exponents that computeraided design (CAD) liberates designers and gives them new ways of envisioning their work, but is this really true? CAD in architecture is examined to see to what extent it has enhanced creativity in design. This is partly done by applying a test of creativity advanced by contemporary architect Herman Hertzberger. In this analysis, CAD is found somewhat wanting, and some suggestions are made as to why this might be so

The Essential Unity of Whitman\u27s \u3ci\u3eLeaves of Grass\u3c/i\u3e, 1855: The Personality Projected

The thesis of this paper is that the essential unity of Whitman\u27s Leaves of Grass, 1855 derives from the personality projected. Up to the present, critics have failed to agree on any single principle of unity in the first poem of Leaves of Grass, 1855, or in the book as a whole. Yet Whitman himself indicated on various occasions over a long span of years that the projection of a personality was his intent. Further, he indicated that this personality could then be utilized for various purposes, most notably he could exploit it to promulge his philosophy. The unity of the twelve Leaves in Leaves of Grass, 1855 is the psychological unity which comes from there being one speaker present throughout the twelve poems, who presents himself and his philosophy to a listener/reader much as he would to a confidante - his thoughts, ideas, visions tumble forth in a non-logical order. The unity of the personality is shown by examining the speaker in the first Leaf in terms of ten significant personality facets, successively, each as through a filter. The first Leaf projects the basic personality which is then expanded and amplified in each of the other eleven Leaves, illuminating the psychological continuity ranging across the twelve poems. The person Whitman projected in the poems thinks, speaks, and acts consistently within the limits of a living personality\u27s idiosyncratic nature and hence provides the essential unity of the book

A behavioural framework for designing educational computer games

Research has indicated that computer games can be innovative and powerful tools for education. Indeed, combining psychological research and games design principles offers a framework for developing educational games that promote learning while maintaining high motivation of the players. If designed correctly, it appears that games can utilize the inherent motivation demonstrated by game players to teach skills that are of immediate practical benefit. The current paper explores “the edges of gaming” in terms of proposing a novel theoretical and methodological framework for the design of educational games

Problem solving in architectural design

This thesis is presented in two parts. The first part is an attempt to set out a framework of factors influencing the problem solving stage of the architectural design process. The discussion covers the nature of architectural problems and some of the main ways in which they differ from other types of design problems. The structure of constraints that both the problem and the architect impose upon solutions are seen as of great importance in defining the type of design problem solving situation. The problem solver, or architect, is then studied. The literature of the psychology of thinking is surveyed for relevant work . All of the traditional schools of psychology are found wanting in terms of providing a comprehensive theory of thinking. Various types of thinking are examined, particularly structural and productive thought, for their relevance to design problem solving. Finally some reported common traits of architects are briefly reviewed. The second section is a report of u~o main experiments which model some aspects of architectural design problem solving. The first experiment examines the way in which architects come to understand the structure of their problems. The performances of first and final year architectural students are compared with those of postgraduate science students and sixth form pupils. On the whole these groups show significantly different results and also different cognitive strategies. The second experiment poses design problems which involve both subjective and objective criteria, and examines the way in which final year architectural students are able to relate the different types of constraint produced. In the final section the significance of all the results is suggested. Some educational and methodological implications are discussed and some further experiments and investigations are proposed

FAK and talin: Who is taking whom to the integrin engagement party?

In this issue, Lawson et al. provide new insight into the relationship between FAK and talin during assembly of integrin adhesions on fibronectin. They show that FAK is upstream of talin, and that talin is not required for FAK recruitment or for integrin activation at nascent adhesions. However, FAK-talin binding is required for adhesion turnover and cell motility. The findings question the view that talin is always upstream of focal adhesion protein recruitment to clustered integrin sites

Weight-based antibiotic dosing in a real-world European study of complicated skin and soft-tissue infections due to methicillin-resistant <i>Staphylococcus aureus</i>

AbstractWe aimed to characterize real-world dosing of weight-based intravenous (IV) antibiotic therapy in patients hospitalized for methicillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft-tissue infections (cSSTIs). This was a subgroup analysis of a retrospective chart review that captured data from 12 European countries. The study included patients ≥18 years old, hospitalized with an MRSA cSSTI between 1 July 2010 and 30 June 2011 and discharged alive by 31 July 2011. Patients treated with IV vancomycin, teicoplanin or daptomycin at any stage during hospitalization were included in this analysis. Analyses were conducted at the regimen level (dosing in mg/kg or in mg, frequency, and total daily dose (TDD)), with potentially multiple regimens per patient, and the patient level, categorizing patients into low, standard (labelled) and high dosing groups according to their initial MRSA-targeted regimen. Among the 1502 patients in the parent study, 998 patients contributed a total of 1050 daptomycin, teicoplanin or vancomycin regimens. Across all regimens, the mean initial TDDs were 6.3 ± 1.9 mg/kg for daptomycin, 10.5 ± 4.9 mg/kg for teicoplanin and 28.5 ± 11.5 mg/kg for vancomycin. A total of 789 patients received first-line therapy with one of the above antibiotics. The majority of patients receiving first-line teicoplanin and daptomycin (96% and 80%, respectively) received higher than labelled cSSTI doses, whereas vancomycin doses were lower than labelled doses in >40% of patients. These real-world data reveal significant deviation from labelled antibiotic dosing in 12 European countries and the potential for suboptimal outcomes in patients with MRSA cSSTIs

How a marine debris environmental education program plays to strengths of linguistically diverse learners

Although environmental education (EE) has increased focus on how to best serve diverse populations, one understudied area is how linguistically diverse learners may engage with EE programming. Linguistic diversity is on the rise across the United States; for instance, nearly one-third of all children between the ages of 0 and 8 have at least one parent who speaks a language other than English in the home. This study evaluated impacts of an EE curriculum designed to promote pro-environmental behavior change with a pre-post, treatment-control experimental design among students from linguistically diverse households. In partnership with teachers, we implemented the curriculum in elementary schools across the state of North Carolina, United States. Over two school years (2018–2020), 36 teachers from 31 schools across 18 counties participated in the study, providing 644 paired pre-post student responses (n = 204 control; n = 440 treatment). About 10% of the sample (n = 49 treatment, n = 18 control) reported speaking a language at home other than English. We tested hypotheses that the curriculum would increase pro-environmental behavior change among all students, but particularly among those from linguistically diverse households using multiple linear regression. Results indicate that the curriculum effectively encouraged pro-environmental behaviors for all students on average, but particularly among linguistically diverse students, adding to growing examples of the equigenic effects of environmental and nature-based education. These findings are consistent with research demonstrating that EE can contribute to behavior change among young learners and may be particularly well-suited to resonate with the unique contributions of linguistically diverse learners

The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation

Epstein-Barr virus (EBV) is a human herpesvirus that persists as a largely subclinical infection in the vast majority of adults worldwide. Recent evidence indicates that an important component of the persistence strategy involves active interference with the MHC class I antigen processing pathway during the lytic replication cycle. We have now identified a novel role for the lytic cycle gene, BILF1, which encodes a glycoprotein with the properties of a constitutive signaling G-protein-coupled receptor (GPCR). BILF1 reduced the levels of MHC class I at the cell surface and inhibited CD8+ T cell recognition of endogenous target antigens. The underlying mechanism involves physical association of BILF1 with MHC class I molecules, an increased turnover from the cell surface, and enhanced degradation via lysosomal proteases. The BILF1 protein of the closely related CeHV15 c1-herpesvirus of the Rhesus Old World primate (80% amino acid sequence identity) downregulated surface MHC class I similarly to EBV BILF1. Amongst the human herpesviruses, the GPCR encoded by the ORF74 of the KSHV c2-herpesvirus is most closely related to EBV BILF1 (15% amino acid sequence identity) but did not affect levels of surface MHC class I. An engineered mutant of BILF1 that was unable to activate G protein signaling pathways retained the ability to downregulate MHC class I, indicating that the immune-modulating and GPCR-signaling properties are two distinct functions of BILF1. These findings extend our understanding of the normal biology of an important human pathogen. The discovery of a third EBV lytic cycle gene that cooperates to interfere with MHC class I antigen processing underscores the importance of the need for EBV to be able to evade CD8+ T cell responses during the lytic replication cycle, at a time when such a large number of potential viral targets are expressed